US scientists said on Sunday they had cleared a key hurdle in the quest for a drug to treat Ebola, a notorious African virus and feared future weapon of bioterrorism.
A treatment administered to rhesus monkeys within an hour of being infected by the deadliest strain of Ebola was 60 percent effective, and a companion drug was 100-percent effective in shielding cynomolgus monkeys against Ebola’s cousin, the Marburg virus.
After studing the findings, the US Food and Drug Administration (FDA) has given the green light for trials on a small group of human volunteers
The Ebola virus, which has a fatality rate of up to 90 percent, is close to being cured. This came about due to the anthrax attacks shortly after September 11. The U.S. military began researching cures and treatments for future anthrax and biological attacks. Those man hours and resources seem to have paid off.
Yesterday, the U.S. Army Medical Research Institute of Infectious Diseases and a private firm, AVI BioPharma, published the results of studies that show that their treatment does have a helpful effect in monkeys. That’s a huge leap, particularly since the reserachers were given clearance to start limited human testing. The partnership won a Defense Department grant of up to $291 million last month for that phase.
It’s an interesting reminder of just how many technological advances have come out of such army research — and who knows, maybe more disease treatments will be down the pipeline. Now, if only they would start researching malaria .
The drugs are in a class of compound called PMO, for phosphorodiamidate morpholino oligomers. They are designed to hamper the virus’ replication in cells, thus buying time for the immune system to mount a response and crush the invader.
Filoviruses are on the list of pathogens such as anthrax that are considered tempting sources for biological warfare or terrorism.
An important step in combatting Ebola was announced in May this year, again using tests on lab monkeys but involving a somewhat different technique to disrupt viral replication.
A team at the US National Emerging Diseases Laboratory Institute at Boston University Medical School designed drugs with small interfering RNAs, or siRNAs, which hamstring reproductive enzymes.
Despite this progress, a long road lies ahead before any treatment is licensed for humans, experts say.
Testing a prototype drug is a three-phase process that starts with a tiny group of volunteers, where it is initially assessed for safety, and then broadens out to successively bigger groups, where effectiveness becomes a parallel question.
According to the UN’s World Health Organisation (WHO), about 1,850 cases of Ebola, with some 1,200 deaths, have occurred since 1976.
The virus has a natural reservoir in several species of African fruit bat. Gorillas and other non-human primates are also susceptible to the disease.
Lets all hope for the best and have another disease bite the dust thanks to medical research.